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Nuovo test per la predisposizione genetica al cancro della mammella e delle ovaie.

23FEB2017
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L’analisi di mutazione dei geni BRCA1 e BRCA2  viene condotta al fine di valutare la predisposizione genetica del paziente allo sviluppo dei tumori alla mammella ed all’ovaio.
I geni BRCA1 e BRCA2 rappresentano i principali geni responsabili della maggior parte dei casi di predisposizione ereditaria per tali patologie.
Una parte dei tumori al seno ed all’ovaio sono cosiddetti sporadici, cioè le mutazioni vengono acquisite casualmente durante il corso della vita, e non vengono trasmesse alla progenie. Una cospicua percentuale dei tumori possono essere ereditari. Si stima che circa il 14% dei tumori alla mammella ed il 10% dei tumori ovarici siano causati da mutazioni ricorrenti a livello del gene BRCA1 e BRCA2.
I tumori ereditari alla mammella ed all’ovaio sono causati da mutazioni ricorrenti a livello della linea germinale che possono essere trasmessi da entrambi i genitori, sia ai figli maschi che femmine, in maniera autosomica dominante, cioè i figli hanno il 50% di probabilità di ereditare la suscettibilità genetica allo sviluppo dei citati tumori.
Le persone che ereditano una mutazione germinale nascono quindi con una copia del gene mutata. Tuttavia è da sottolineare che questi soggetti non ereditano il tumore, ma solamente la predisposizione a sviluppare il tumore. Non tutte le persone che sono portatrici di mutazione sviluppano la patologia neoplastica; sebbene queste mutazioni aumentano notevolmente il rischio di insorgenza del tumore, questo non si sviluppa finché la copia normale del gene corrispondente non viene soggetta a mutazione nel corso della vita. Infatti, poiché ciascuna persona eredita due copie dello stesso gene, deve incorrere un evento mutazionale in ciascuna copia per sopprimere la funzione di quel gene; l’acquisizione di una nuova mutazione può quindi provocare direttamente l’insorgenza del tumore.

STATISTICHE DI RISCHIO

Tumori alla mammella

A seguito di approfonditi studi effettuati su famiglie a rischio, è stato accertato che le donne che possiedono mutazioni ereditarie a livello dei geni BRCA1 o BRCA2 rischiano di sviluppare un tumore alla mammella nell’87% dei casi, contro una probabilità del 10% dei non portatori di mutazioni. Le mutazioni ereditarie a livello di tali geni determinano nelle donne un sensibile aumento del rischio di sviluppare un tumore al seno in età precoce (prima della menopausa), rappresentando quindi una caratteristica peculiare della suscettibilità ereditaria. Recenti studi hanno, infatti, dimostrato che più della metà delle donne portatrici di mutazioni a livello dei geni BRCA sviluppa un tumore al seno prima dei 50 anni, con un’età media di diagnosi del tumore di 41 anni.

Tumori ovarici

Il rischio di sviluppare un tumore ovarico in caso di ricorrenza di mutazioni in uno dei due geni in questione è, invece, compreso tra il 44-60%, rispetto all’1% di probabilità dei non portatori.

Ricorrenze

Il test di suscettibilità genetica è molto utile anche per quelle donne che hanno già sviluppato un tumore alla mammella in quanto, se portatrici di mutazioni BRCA, sono ad alto rischio di sviluppare un nuovo tumore alla mammella o un tumore all’ovaio. Per esempio, è stato accertato che donne portatrici di mutazioni BRCA1 che hanno già avuto un tumore alla mammella, rischiano di sviluppare un nuovo tumore nel 64% dei casi. Percentuali di rischio simili sono previste per il tumore ovarico.

Rischio di insorgenza di altri tipi di tumore

Recenti studi hanno riportato che le mutazioni ereditarie dei geni BRCA1 o BRCA2 aumentano sensibilmente il rischio di tumori alla prostata nell’uomo e di tumori al colon in entrambi i sessi. Il rischio di tumore alla prostata è stato valutato essere 3-4 volte maggiore rispetto alla popolazione generale nell’uomo portatore di mutazione BRCA, con un rischio cumulativo dell’ 8%, mentre il rischio del tumore al colon è stato valutato essere 4-5 volte superiore, sia nelle donne che nell’uomo, con un rischio cumulativo del 6%.

INTERPRETAZIONE DEI RISULTATI

Il test genetico determina se una persona presenta o meno delle mutazioni a livello del gene BRCA1 o BRCA2.
Un risultato positivo significa che sono state identificate una o più specifiche mutazioni, e quindi può essere stimato in termini probabilistici il rischio di sviluppare il tumore associato a quel tipo di mutazione.
Non tutte le donne con mutazioni a livello di BRCA1 o BRCA2 sviluppano la patologia neoplastica, ma il rischio è abbastanza alto. Sebbene la malattia sia rara per il sesso maschile, un uomo che presenta mutazioni di BRCA1 o BRCA2 possiede un rischio maggiore di sviluppare un tumore alla mammella.
Un risultato negativo significa che non è stata riscontrata alcuna mutazione. Tuttavia è importante sottolineare che un risultato negativo non significa che la paziente ha rischio zero di sviluppare un tumore al seno o all’ovaio; queste donne possiedono lo stesso rischio di tumore riportato per la popolazione generale, ciò perché la maggior parte di questo genere di tumori si estrinseca in forma sporadica, per cause ancora non ben conosciute.

CARATTERISTICHE DEI GENI BRCA1 E BRCA2

BRCA1 e BRCA2 sono geni onco-soppressori localizzati rispettivamente sul cromosoma 17 e sul cromosoma 13. Nelle persone predisposte geneticamente, la perdita della funzione di gene onco-soppressore è dovuta a eventi mutazionali ricorrenti a livello del citato gene, con conseguente produzione di una proteina anormale.
Le mutazioni ricorrenti a livello di questo gene costituiscono la causa della maggior parte dei casi di tumore ereditario alla mammella ed all’ovaio.

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    Camping is a superb process, but there are some threats associated with it. There are many normal hazards inside the wild which can be risky and also lethal to travelers should they experience them. The following post could keep you harmless by showing you what threats to look out for when camping. Were you aware that a straightforward mirror can help to save your way of life? If you are camping and wind up in a emergency condition, a basic handheld vanity mirror can be used to signal for support numerous kilometers out. Do not find the standard cup match, many outdoor camping source stores sell wall mirrors made from Lexan that may drift and are practically unbreakable. In relation to food, provide only what exactly you need with a camping out journey. Added foods out in the backwoods is a getting in touch with cards for outdoors pets in the future checking out your campground. If you do discover that you have extra food, tie it up in fabric and handg it up to you can inside a tree away from your fast camping site. This will aid keep you from undesired pet introductions. Generally go on a entirely filled very first-aid kit whenever you endeavor out on a camping outdoors journey. You may put together your personal system with bandages, gauze patches, tweezers, scissors, anti- germs lotion and germ killing baby wipes in a strong pot. Also you can acquire among the many superb completely ready-made packages to save lots of time. In case you have a young kid together with you, do the arithmetic ahead of time regarding just how much baby food or formulation they will likely need. Be sure you have products for these people that will very last the whole time period of your vacation. There are no guarantees that the shop around your campsite can have these things or can have the type of things you want. Outdoor camping is a fairly basic outdoor adventure for just about anyone to deal with. But this short article distributed some good info that should assist you to industry any damages that could come the right path prior to they actually are able to become issue for yourself. Continue to keep this data under consideration on your own enjoyable camping out vacation!

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  • Pamula Spannaus

    • 18 Agosto 2020, 12:28

    Not a lot is preferable to sleeping within the night skies with the family. Camping out is an excellent interest to get a cause. While it could be exciting, there is lots to remember when camping out. These paragraphs have helpful ideas will prepare yourself for your camping outdoors journey. Bring along a sleeping case right for the time of year. If you use a heavy winter season sleeping handbag in summer, this can be stifling and unpleasant. If you utilize a lightweight sleeping case during the winter months, you are able to spend your night time shivering if it’s frosty outdoors. You might even develop hypothermia. If you are going with a outdoor camping experience, ensure you have plenty of time to set up camp out well before darker. It can be extremely hard to put together camping at night and perhaps dangerous. You have to be able to search the landscape, make home bedding, and perhaps build some short-term shelter before the sunshine going down. When you are planning a camping outdoors journey, make sure you package the correct garments for the vacation. Examine the climate predict and provide the apparel that can be necessary on your own vacation. If it is going to be cool, be sure to get the proper jackets, safety gloves, and shoes. Make sure to also load up a rain poncho irrespective of what the weather forecast forecasts. Whilst you have this vision of any entertaining-packed camping out trip, frequently scrapes and slashes just manage to feature all of that entertaining. Make sure you have a initially-help package with you into nature simply because incidents just take place, and it’s always safer to be secure than sorry. Hopefully, it is going to stay stuffed safely out, but you will get the satisfaction you are prepared if one thing does happen. Provide sufficient food items and snack food things to endure during the entire complete trip. You don’t would like to spend your time going to get food items every meal, have fun when you are camping. Take cereal, hot dogs, as well as your other favored food items which will fuel you during your journey. The potential for camping outdoors journeys to be unique vacation trips that will be appreciated long into the future is great. Nevertheless, in order to be prepared for anything that might occur as you go along, some progress research will make all the difference. The preceding write-up need to hopefully provide the appropriate start for just about any soon to be camper.

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  • Shawanna Secondo

    • 18 Agosto 2020, 21:03

    It’s constantly essential to do a little research about camping out well before placing away in your trip. There are plenty of different things that can come about when you are available. It doesn’t injured to be ready, and could help you save lots of trouble. The following is some advice to assist you to possess the greatest outdoor camping vacation feasible. Even though it is really not an essential part of your own again nation camping outdoors products, a machete is something that you might take into account loading according to where you are going. It is a really adaptable tool inside the wilderness. You are able to reduce a pathway, crack bamboo and vines for shelter, minimize coconuts for water, dice fire wood, and in many cases make use of it as protection against wild pets. An effective multiple-objective device needs to be a part of your camping outdoors items. There are 2 types to give. First is the saw/hammer/axe 3-in-1 instrument to use for fire wood and other duties. Another may be the regular multi-function resource with a variety of equipment on it just like a can opener, tweezers, scissors, as well as a blade. An important mistake that outdoorsmen make is that they can get lost occasionally. Usually do not allow this to eventually you. When you are not familiar with the area you will be outdoor camping in or in case you are in a wilderness place, will not stray too much out of your campsite. A portable Gps navigation is a great purchase if you are intending any sort of wilderness outdoor camping journey. Over-packaging surpasses under-packaging with regards to kids. Camping outdoors could be messy. Your children might really like playing around in the grass and soil. Which means you must prepare to have filthy children. While this could not generally be averted, be sure you load additional garments. There exists nothing like being prepared! Camping outdoors journeys with your family become the memories of story. Often these thoughts are excellent, occasionally they can be bad. To offer your following outdoor camping journey the best chances of good results, apply every one of the ideas that you may have go through in this article. They may serve as the tent of information that safeguards you.

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  • Nicolas Rottinghaus

    • 20 Agosto 2020, 4:41

    Having the family jointly for any camping out adventure may be some very nice entertaining for everybody involved. When preparation your outdoor camping journey, getting some very nice suggestions and suggestions makes the variation in your enjoyment too. Check out this informative article to soak in outstanding ideas which will have you ever out the front door and in the excellent in the open air quickly. Duct tape is very important to bring along due to the fact you can use it for any very good bit of things. You can use it as a speedy patch for camping tents, boots, inflatables, or enables you to protect things for example your mosquito netting. Pre-great your an ice pack upper body by stuffing it with loads of ice, at the very least 6 hours just before leaving. While you are intending to abandon, load up the refrigerated cooled beverages and prevent ice cubes, not cubed. Popping room temp drinks will take up beneficial ice-life, and the cubes will dissolve much faster than a block! Load up what is essential for your children. Camping outdoors can be quite a careless time. Little ones just want to get messy. While they begin experiencing the natural setting, you may find that debris is put into soil. As there is absolutely nothing that can be done about that, you might have additional apparel in the event that. Usually get ready! All those large, multi-colored plastic storage space containers make excellent locations to keep and manage all of your current camping out gear. Whilst in the home, ensure that is stays in a cabinet or the car port and proper before you leave to your camping getaway, put it from the trunk. It ought to always keep every little thing air-small, dry and simply available. As previously mentioned, increasingly more family members are being forced to forego traditional loved ones vacations due to economic limitations and as an alternative select basic camping out travels towards the wonderful outside. Hopefully, reading this informative article, you really feel prepared to strategy the best camping out adventure that you and your family can bear in mind for a lifetime.

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  • Dennis Montore

    • 20 Agosto 2020, 14:02

    Anything as relatively simple as outdoor camping might appear just like little preparation is important. This is not the case. The more effective organizing one does, the more exciting you can have. The following will help you in finding the best plan for your next outdoor camping trip so that you are ready for something. One of the more important elements of your camping out products is your tent. The tent you get ought to satisfy your desires and the dimensions of your camping out bash. If you have children, you probably wish to buy a sizeable tent to enable them to sleep from the identical tent with you. When your children are aged, purchase them their very own tent so they don’t ought to bunk together with the adults. If you are searching for outdoor camping, and you also are a new comer to the activity, you then must not start off alone. It can be very risky should you don’t know what you are actually carrying out, so it is important to bring along a highly skilled buddy to assist you find out the ropes. A large concern with many individuals who go outdoor camping is the little bugs. Will not find yourself in trouble during not anywhere without the need of some type of bug repellant. Check your area well before putting together camp for virtually any wasp nests or ant mountains that may give you problems. Wear long trousers and very long-sleeved whenever you can and inspect on your own for ticks occasionally. Whenever you attain your campsite, the first thing, you must do is to commence accumulating hardwood for your fireplace. You won’t seem like it later on, and if you hold back until dark you will have a tougher time discovering the kind of timber you must keep a flame heading. Do it right aside. To terminate, you need to retain the assistance and tips in imagination while you are out and approximately on your own camping outdoors journey. Nobody wants into the future home coming from a vacation because of becoming frustrated since they had been not aware of what they needed to know upfront. Good luck and enjoy yourself!