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Test delle urine apre una speranza per la diagnosi precoce del tumore al pancreas

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UN SEMPLICE TEST delle urine potrebbe permettere di diagnosticare precocemente il cancro del pancreas, un tumore che oggi nell’80% dei casi viene individuato quando è ormai in fase avanzata, non più operabile. Un tipo di tumore che fa registrare il più basso tasso di sopravvivenza a 5 anni (il 3%) rispetto a ogni altra neoplasia comune. Ora un gruppo di scienziati inglesi e spagnoli ha scoperto nelle urine una sorta di ‘firma’ della malattia: 3 proteine (LYVE1, REG1A e TFF1) presenti in concentrazioni elevate solo nei pazienti con carcinoma pancreatico. La ricerca è stata pubblicata su Clinical cancer research,

Il test su 500 campioni. Nel corso dell’analisi sono stati analizzati 500 campioni di urina: meno di 200 prelevati da pazienti con cancro al pancreas, 92 da persone con pancreatite cronica, 87 da volontari sani e i restanti da pazienti con lesioni benigne o tumorali a fegato e cistifellea. Delle 1.500 proteine trovate nei campioni, LYVE1, REG1A e TFF1 sono risultate più alte nelle persone con tumore pancreatico, e più basse nei pazienti con pancreatite cronica. Le 3 sostanze potrebbero dunque rappresentare una ‘firma proteica’ del tumore. Benché siano necessarie ulteriori indagini, che riguarderanno in particolare gli individui a maggior rischio genetico di ammalarsi, la novità viene accolta con entusiasmo da ricercatori e associazioni.

“Un risultato entusiasmante”. “E’ davvero emozionante – commenta Nick Lemoine del Barts Cancer Institute britannico, co-autore dello studio, citato dalla Bbc online – perché per la prima volta potremmo essere in grado di offrire ai pazienti con cancro al pancreas l’opportunità di passare dalla diagnosi di un tumore avanzato a quella di una lesione allo stato iniziale, potenzialmente curabile con la chirurgia”. Un “risultato entusiasmante” anche per il Charity pancreatic cancer research fund, che sottolinea come di un test per la diagnosi precoce della malattia ci sia “davvero molto bisogno”. Nei pazienti in cui il carcinoma viene scoperto “in stadio 1 – conclude Lemoine – il tasso di sopravvivenza può arrivare al 60%”.

Diagnosi tardive. L’esame delle urine potrebbe aprire una nuova strada per la diagnosi di questo tumore che spesso viene diagnosticato in ritardo. Le persone più a rischio sono quelle con altri casi in famiglia, i fumatori, gli obesi e gli over50 con una diagnosi recente di diabete. Purtroppo il cancro del pancreas in fase precoce non dà segni particolari, e anche quando sono presenti sintomi si tratta di disturbi piuttosto vaghi, che possono essere interpretati in modo sbagliato. Per questi motivi la diagnosi spesso viene fatta quando la malattia è già estesa. Sintomi più chiari compaiono successivamente. Possono così manifestarsi perdita di peso e di appetito, ittero, che porta a una colorazione gialla della pelle, dolore nella parte superiore dell’addome o nella schiena, debolezza, nausea o vomito. Infine, una percentuale di malati che va dal dieci al venti per cento può essere anche colpita da diabete, dovuto all’incapacità delle cellule malate di produrre insulina. Ogni anno sono oltre 10.000 le persone colpite dal tumore del pancreas in Italia. Si stima che ogni anno si manifestino 5.500 casi tra gli uomini e 5.900 tra le donne

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