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“Un’iniezione per fermare il tumore alla prostata”

11NOV2014
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Lo studio delle università di Bristol, Nottingham e della University of the West of England. Messo a punto un sistema per ‘bloccare’ la molecola che aiuta il cancro a formare nuovi vasi sanguigni e quindi a sopravvivere e diffondersi nel corpo

"Un'iniezione per fermare il tumore alla prostata"

Un’iniezione per bloccare il tumore. Inibendo l’attività di una molecola chiave è possibile fermare la diffusione del cancro alla prostata. Uno studio delle università di Bristol, Nottingham e della University of the West of England (UWE Bristol), ha messo a punto un composto specifico in grado di bloccare l’attività della molecola SRPK1, che aiuta i tumori a formare nuovi vasi sanguigni e quindi a sopravvivere e diffondersi nel corpo.

La molecola SRPK1. Per arrivare a questo risultato, pubblicati sulla rivista Oncogene, i ricercatori hanno analizzato campioni umani di cancro alla prostata. In questo modo e’ stato possibile osservare che un aumento della SRPK1 e’ legato a una maggiore aggressività del tumore. In seguito i ricercatori hanno dimostrato che farmaci noti come composti SPHINX, progettati per inibire specificamente l’attività di SRPK1, sono in grado di ridurre la crescita tumorale in un modello murino di cancro della prostata, quando questi vengono somministrati tre volte alla settimana con iniezioni. “I nostri risultati indicano un nuovo modo di trattare i pazienti affetti da cancro alla prostata e possono avere implicazioni più ampie per il trattamento di altri tipi di tumori”, hanno concluso i ricercatori.

Bloccare il tumore. “Abbiamo capito che c’era un collegamento fra l’attività della molecola SRPK1 e l’espansione del tumore – ha detto Sebastian Oltean, coautore dello studio e ricercatore della University of Bristol’s School of Physiology and Pharmacology – . Con questa nostra sperimentazione abbiamo dimostrato che facendo calare i livelli dell’SRPK1 potevamo ‘inibire’ il tumore alla prostata.”

Il test sui topi. I tumori hanno bisogno di sangue per sopravvivere e crescere. Gli studiosi hanno visto che bloccando i vasi sanguigni è possibile frenare l’espansione delle cellule cancerogene. Hanno creato una miscela che hanno sperimentato sui topi. Le iniezioni sugli sulle cavie da laboratorio riuscivano a fermare la molecola SRPK1 e a quel punto la crescita del cancro si fermava.

Contro altri tipi di cancro. La prossima tappa della sperimentazione è quella di sviluppare un medicinale che possa influire sull’attività della molecola SRPK1. Dal momento che questo tipo di cura punta ad agire sui vasi sanguigni, può essere usata anche per combattere altri tipi di tumore e anche la degenerazione maculare legata all’età, che porta a cecità.  “I nostri risultati propongono una nuova via per trattare il tumore alla prostata e potrebbero avere un’applicazione molto più ampia, per altri tipi di tumore”, spiega l’altro autore dello studio, David Bates della University of Nottingham’s Division of Cancer and Stem Cells.

La super risonanza magnetica. Intanto proprio in questi giorno è stata presentata una risonanza magnetica di ultima genereazione. Si chiama risonanza magnetica ‘multiparametrica’ e secondo uno studio dell’Ieo (Istituto europeo di oncologia) di Milano, che ne ha valutato il ruolo nella diagnosi e nella cura del tumore alla prostata, questa tecnica speciale può diminuire i più temuti effetti collaterali del trattamento anticancro – impotenza e incontinenza – a parità di efficacia oncologica. La ricerca su 278 pazienti con tumore prostatico in due anni, è stata pubblicata su ‘Radiology‘.

I dati. Il tumore alla prostata è una delle forme di cancro più diffuse tra gli uomini. In Italia i casi sono in calo. Per il 2015 sono attesi circa 35.000 nuovi casi, con una caduta rispetto a quelle che erano le stime degli anni precedenti legata al perfezionamento dei metodi predittivi e delle diagnosi precoci. Cala, inoltre, anche il tasso di mortalità causato dal carcinoma prostatico. Secondo le ultime stime, infatti, in Italia nel 2015 saranno 323.000 le persone con diagnosi di tumore alla prostata che sopravvivranno e il 50% dei 35.000 nuovi casi sono classificati a basso rischio. Per questi ultimi, quindi, si potrà così parlare di “sorveglianza attiva” e, forse presto, non sarà più necessario sottoporre tali pazienti a operazioni chirurgiche.

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